netstat -apn|grep 80  

0 0.0.0.0:80                  0.0.0.0:*                   LISTEN      2070/nginx    
KILL掉2070

kill 2070

重新加载

/usr/local/nginx/sbin/nginx -s reload
[error]: open() "/usr/local/nginx/logs/nginx.pid" failed (2: No such file or directory)

如果继续报错执行以下语句

/usr/local/nginx/sbin/nginx -c /usr/local/nginx/conf/nginx.conf
/usr/local/nginx/sbin/nginx -s reload